Rika Inaba is a beautiful and strong-headed director at the Teito Television Broadcasting Company. Ever since she was young, she had dreamed of becoming the best news reporter in the business, but on into her fifth year with the TV station, she finds to her dismay she's been transferred to a lighter fare, information program where she is assigned to report on the Japan Air Self-Defense Force. Meanwhile, Daisuke Sorai had just reached his long-sought goal of becoming an aerobatics pilot only to injure his leg, crushing his chances at ever becoming a member of the elite Blue Impulse flying team. He gets assigned to the force's public relations desk and subsequently finds himself attached to Rika in the role of attendant. Sorai and Rika differ on just about everything; their views, their mindset. But they share one thing: their childhood dreams have been shattered and they've hit a wall in life. From there, a mutual understanding begins to germinate, drawing them toward each other and toward the discovery of a new dream.

It is the year 2194. The Gamilons, an enemy of undetermined form, begin an invasion of Earth. The nations of Earth pool their forces and fight back, but their armies are defeated and most of humanity wiped out. Five years later, in 2199, the Earth has been polluted by space-to-planet bombs, and those who remain alive have fled underground. Even the former top pilot, Susumu Kodai, has left the military. One day as he is exploring above-ground, a mysterious object falls out of the sky. This is a communications capsule from the planet of Iscandar, 148,000 light years distant. Apparently on Iscandar is equipment that will eliminate the radiation. The Defense Force of Earth equips the Space Battleship Yamato with a previously unknown propulsion system, a ‘wave-motion engine’ based on plans found in the capsule. Kodai rejoins the Force, and resolves to set out aboard the "Yamato." With the fate of the Earth in their hands, the crew blasts off for distant Iscandar. They have one year until radiation drives humanity to extinction. Kodai’s great battle has begun. Carrying humanity’s last hope with it, the Yamato blasts off!

At the Tojo University Hospital, a group of specialists in the type of heart surgery called the “Batista operation,” which is said to have a success rate of 60%, have formed a specialist team called “Team Batista,” and the team is improving their record miraculously with 26 consecutive successful cases. However, all of a sudden, there are three operational death cases in a row. Are they just accidents? Or murders? A doctor, Taguchi is assigned to conduct an internal investigation. Taguchi, who knows nothing about surgery, reluctantly plays the role of a detective, but, not surprisingly, things don’t work. When Taguchi is trying to wrap up her investigation by determining that those operational deaths are simply accidents, a daring and astute government official of the Ministry of Health, Labor and Welfare named Shiratori shows up in front of Taguchi, saying “These are murder cases. The suspect is among the 7 members of Team Batista!” The two investigate the Team Batista members once again…

Kasumi is shocked to discover that her older sister’s fiance is the man she first fell in love with five years ago in high school. At the time, he was her high school teacher and ultimately quit his job racked with guilt over their relationship. Kasumi was deeply hurt and struggled for a long time to overcome her sadness. Now the two of them must come to terms with their secret past before the ones they care about in the present are hurt.

Kyoko, a young woman with an unhindered spirit despite being physically bound to a wheelchair due to illness, and Shuji, a stylish and popular fashion magazine hairstylist, are brought together in a fateful traffic incident. Despite their confrontational meeting, they soon find themselves falling in love, with Shuji drawn to her courage and enthusiasm and Kyoko attracted to his ability to look beyond her physical limitations and into her heart. However, Kyoko’s protective older brother and her worsening condition begin to test the bounds of their love for each other and threaten to end their beautiful life together.