Nao Kitazawa, 34, leads a busy but fulfilling life as a doctor at a women’s clinic and as fiancee to an elite psychiatric physician, Yuchi Ihara. With their wedding day a month off, Nao is preparing to move into a new home when she meets Shinji Mamiya, a struggling writer who works part-time as a mover and falls inexorably in love with him. The fateful encounter compels Nao to follow her heart and experience true love. Overwhelmed by Nao’s passion, Shinji soon falls for her as well, but their budding romance is threatened by the tragic discovery that Nao has early onset Alzheimer’s. What unfolds is a story of pure love. As Nao’s symptoms worsen, Shinji spends the next ten years giving Nao mental and health support even as she begins to lose the precious memories they both shared.

Racing to the sites of horrific disasters and accidents, a medical team specializes in disaster treatment “under the rubble.” They are DMAT, the Disaster Medical Assistance Team, and their mission is to rescue disaster victims from the grips of imminent death with quick response emergency aid. Internal medicine physician, Dr. Hibiki Yakumo, intentionally avoided the field of emergency care after a misjudgment led to his younger sister slipping into a comastose state in ER. But when hospital director, Shoichi Isezaki, transfers him to DMAT, he joins a an elite yet very eccentric team of doctors and nurses. When they respond to a highway tunnel multiple collision with large casualties, Hibiki must confront a mind-boggling scene of tragedy where 10 seconds of hesitation could mean the loss of life. A human drama unfolds in extreme life or death conditions.

Ando, the head of prestigious Izumida Hospital, drafts Takashi, a battle-hardened and brilliant surgeon. On his first day, he meets Detective Mizusawa who has brought in a critically injured criminal whom she was forced to shoot. Against the wishes of his superior, Takashi miraculously saves the criminal. Takashi learns of another patient in the hospital that has been in a coma for 21 years. Takashi suggests a way he may be able to revive the man, but is stubbornly opposed by Ando. This arouses Takashi's suspicions that Ando may have a personal stake in keeping the patient in a vegetative state; and he and Detective Mizusawa set out to unravel the mystery behind this 21-year old incident and ultimately learn more about their mutual past in the process.